Igm-enriched polyclonal immunoglobulins in an experimental model of gram negative pneumonia developing septic shock

Introduction Severe pneumonia is a major challenge in the Intensive Care Unit, as it is characterized by high morbidity and mortality. A high rate of patients with pneumonia, in particular ventilator-associated poneumonia, develops septic shock. Although some interesting results have been reported in uncontrolled studies where IgMenriched human intravenous immunoglobulins were added to the standard treatment of septic shock, a wellconducted clinical trial is missing [1]. Also, physiopathological data supporting such a trial are presently insufficient.